Author: admin_alscvf8679

Is ALS genetic?
14 Jun 2022admin_alscvf8679

There is a lot of debate surrounding whether or not ALS is genetic. Some people believe that it is, while …
ALS in Women: Symptoms and Treatment Options
14 Jun 2022admin_alscvf8679

ALS, or amyotrophic lateral sclerosis, is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. …
ALS Diagnosis: How is ALS diagnosed?
10 Jun 2022admin_alscvf8679

How is ALS diagnosed? This is a question that many people have, especially after the Ice Bucket Challenge went viral …

Presynaptic FMRP and local protein synthesis support structural and functional plasticity of glutamatergic axon terminals 06/20/2022

Monday, Kharod et al. report that neuronal activity regulates presynaptic FMRP function and the local synthesis of β-actin. In vitro activity and in vivo experience engage the FMRP-dependent spatiotemporal regulation of protein synthesis that is required for presynaptic remodeling and long-term changes in neurotransmitter release.

Neural mechanisms of credit assignment for inferred relationships in a structured world 06/16/2022

Witkowski et al. show that prefrontal cortical areas both track the inferred “position” in a task space defined by hierarchically related associations governed by a common latent cause and reinstate these latent causes at feedback to assign credit to the inferred associations.

Sodium-calcium exchanger-3 regulates pain “wind-up”: From human psychophysics to spinal mechanisms 06/14/2022

Repetitive noxious stimuli increase pain perception (wind-up). Trendafilova et al. demonstrate significant genetic association between the sodium-calcium exchanger NCX3 and human wind-up. Mice lacking NCX3 show increased pain-related behavior and spinal hyper-excitability due to slowed Ca2+ clearance. Enhanced spinal expression of NCX3 reduced pain in mice, suggesting therapeutic potential.

Medial and orbital frontal cortex in decision-making and flexible behavior 06/14/2022

The prefrontal cortex (PFC) provides high-level coordination of behavior but is not a homogeneous structure. In this review, Klein-Flügge et al. compare the function of several distinct PFC regions and connected subcortical nuclei in decision-making, behavioral flexibility, and social behavior.