Author: admin_alscvf8679

Life With ALS: The Stephen Hawking Story
24 Feb 2023admin_alscvf8679

Stephen William Hawking is one of the most influential and inspirational figures of modern times. Diagnosed with a neuromuscular disease …
Signs You Don’t Have ALS and How to Tell if You’re At Risk
16 Jan 2023admin_alscvf8679

Most people have never heard of Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s Disease. It is a rare …
Is ALS genetic?
14 Jun 2022admin_alscvf8679

There is a lot of debate surrounding whether or not ALS is genetic. Some people believe that it is, while …

Presynaptic α2δs specify synaptic gain, not synaptogenesis, in the mammalian brain 05/13/2025

Milanick et al. uncover that presynaptic α2δs are positive regulators of Munc13-1 levels, an essential neurotransmitter release protein, but mammalian synapse development, ultrastructure, and presynaptic CaV2.1 organization are independent of α2δs. Their results define the presynaptic α2δ regulatory roles and suggest a new α2δ role in controlling synaptic strength and plasticity.

The estrous cycle modulates hippocampal spine dynamics, dendritic processing, and spatial coding 05/13/2025

In this study, Wolcott et al. explore estrous-cycle modulation of hippocampal neuron structure and function. Using longitudinal two-photon imaging across the estrous cycle, they find significant modulation at the synaptic, cellular, and population levels.

NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming 05/13/2025

(Neuron 109, 4094–4108.e1–e5; December 15, 2021)

Neural circuit underlying individual differences in visual escape habituation 05/09/2025

Liu et al. reveal distinct subcortical pathways from the superior colliculus to the amygdala and insula cortical pathways that govern two visual escape behaviors in two groups of mice, offering new insights into arousal modulation, internal states, and adaptive responses to visual threats.