Category: Uncategorized

ALS in Women: Symptoms and Treatment Options
14 Jun 2022admin_alscvf8679

ALS, or amyotrophic lateral sclerosis, is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. …
Living with Chronic Sinusitis: What Is It Like for ALS Patient?
20 Jan 2021admin_alscvf8679

Living with chronic sinusitis is having frequent nasal infections. This sinus problem can be troublesome and hinder life to its fullest. How about more if you have the condition that weakens your muscle movement and at the same time living with chronic sinusitis? How will you manage your sinus infection from this condition called Amyotrophic Lateral Sclerosis (ALS)? This article will help you understand what is chronic sinusitis and what it is like for ALS patient.
What Are The Risks Of Having Primary Lateral Sclerosis? (Basic Details)
20 Mar 2020admin_alscvf8679

The central nervous system (CNS) is probably one of the most if not the top sensitive parts of our body. Our mind and body functions simultaneously, thanks to our brain and nerves. However, any disruption, blockage, or destruction in these nerves may lead to problems that affect the whole movement of legs, arms, and voluntary muscles that a person have. ALS or Amyotrophic lateral sclerosis is similar to progressive primary lateral sclerosis as both can hinder neurons for motor movement.

An evolutionary perspective on complex neuropsychiatric disease 11/27/2023
Members of the NIMH Network for Studies of Mental Disorders in Ancestrally Diverse Populations illuminate the genetic architecture of complex neuropsychiatric illnesses in the context of forces of evolution: mutation, selection, migration, and genetic drift/population structure.
Striatal dopamine integrates cost, benefit, and motivation 11/27/2023
Eshel et al. combine economic analyses with dopamine recordings and manipulations to find that dopamine release in the striatum encodes both the magnitude of a reward and how much the mouse has worked for it. Furthermore, the higher the mouse’s motivational level, the lower the reward-evoked dopamine release.
Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1 11/27/2023
In neurodegeneration, vulnerable neuronal populations are highly influenced by concomitant changes in surrounding cells, including glia. Here, Tejwani et al. performed longitudinal single-nucleus profiling of the mouse and human SCA1 cerebellum, which elucidated the progressive dysregulation of Purkinje cells and revealed early transcriptional changes in oligodendroglia and unipolar brush cells.
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist 11/22/2023
Using lipidomics coupled with immunostaining, Litvinchuk et al. demonstrate that ApoE promotes changes in cholesterol metabolism and lipid accumulation in glia of 9.5-month-old P301S mice. LXR agonist GW3965 diet and Abca1 overexpression markedly decrease tauopathy, neurodegeneration, synapse loss and behavioral deficits, neuroinflammation, and glial lipid accumulation in 9.5-month-old P301S/ApoE4 mice.