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Other Informations About Neurons

Translation of GGC repeat expansions into a toxic polyglycine protein in NIID defines a novel class of human genetic disorders: the polyG diseases 04/21/2021

The neurodegenerative disease NIID is caused by an expansion of GGC repeats in NOTCH2NLC. Boivin et al. found that these repeats are translated into a toxic polyglycine (polyG) protein that forms intranuclear inclusions. An identical mechanism exists in FXTAS, unveiling a novel group of genetic pathologies, the polyG diseases.

Fast, cell-resolution, contiguous-wide two-photon imaging to reveal functional network architectures across multi-modal cortical areas 04/19/2021

Ota et al. present fast and wide field-of-view two-photon microscopy with practically no optical aberrations. Combining high-performance large lenses and devices and a fast laser-scanning engine enables the recording of >16,000 neurons in awake mice. Functional network analysis with single-cell resolution reveals the small-world connectivity of the cortex.

Mesoscale cortical dynamics reflect the interaction of sensory evidence and temporal expectation during perceptual decision-making 04/15/2021

Orsolic et al. reveal how the mouse neocortex is modulated by sensory evidence in a visual change detection task. They show that recruitment of the secondary motor cortex emerges with learning and reflects the interaction of sensory evidence and prior knowledge of task structure.

Coordination of escape and spatial navigation circuits orchestrates versatile flight from threats 04/15/2021

Wang, Schuette et al., show that the hypothalamic dorsal premammillary nucleus (PMd), but not other hypothalamic nuclei, controls versatile escape from threats as well as panic-related simple flight in mice. The PMd engages spatial navigation outputs in the thalamus only during context-specific versatile escape. In contrast, the PMd recruits brain stem outputs during context-specific and panic-related […]