Contact Us - ALS Curtis Vance Foundation

NMDA Receptors Require Multiple Pre-opening Gating Steps for Efficient Synaptic Activity 12/01/2020
NMDA receptors are neurotransmitter-gated ion channels that regulate higher brain function. Using a unique technique to assay neurotransmitter-induced opening of the ion channel and available high-resolution structures, Amin et al. provide a framework to understand the structural underpinnings that regulate the activity of NMDA receptor activation at synapses.
Hyperscanning: Beyond the Hype 11/30/2020
Hyperscanning—the recording of brain activity from multiple individuals—can be hard to interpret. This paper shows how integrating behavioral data and mutual prediction models into hyperscanning studies can lead to advances in embodied social neuroscience.
Differential Synaptic Input to External Globus Pallidus Neuronal Subpopulations In Vivo 11/27/2020
Ketzef and Silberberg describe the membrane properties, synaptic inputs, and sensory responses of prototypic and arkypallidal cells of the external globus pallidus using in vivo whole-cell recordings and optogenetics. They show differential integration of direct, indirect, and hyperdirect basal ganglia pathways performed by the respective cell types.
Behavioral, Physiological, and Neural Signatures of Surprise during Naturalistic Sports Viewing 11/25/2020
Antony et al. derive a model tracking surprise during naturalistic basketball viewing and find many links to behavioral, physiological, and neural measures, including predicted changes in neural patterns. Their findings test and support key ideas in event segmentation theory and provide face validity for multiple laboratory findings about surprise.