Category: ALS

Is ALS Painful? Unpacking the Complexities of Pain in Lou Gehrig’s Disease
15 Jul 2024admin_alscvf8679

When discussing Amyotrophic Lateral Sclerosis (ALS), a common question arises, iIs ALS painful? This progressive neurodegenerative disease affects nerve cells …
Does ALS Cause Numbness? Exploring Symptoms of Amyotrophic Lateral Sclerosis
10 Jun 2024admin_alscvf8679

Does ALS cause numbness? This question often arises for those trying to understand the complex symptoms of amyotrophic lateral sclerosis. …
Is ALS Contagious? Unveiling the Facts Behind Transmission
9 May 2024admin_alscvf8679

Is ALS contagious? This is a crucial question many ask when they first encounter amyotrophic lateral sclerosis, a neurodegenerative disease …

Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states 11/25/2025
Ährlund-Richter et al. show that in mice, discrete subregions of the prefrontal cortex send distinct feedback signals to the primary visual cortex. These pathways differentially modulate visual processing depending on behavioral state, revealing how higher-order cortical areas dynamically influence sensory representations to integrate perception with internal state.
Ultrastructural membrane dynamics of mouse and human cortical synapses 11/24/2025
Eddings et al. illustrate that synaptic membrane trafficking can be studied with millisecond resolution in resected human brain tissues using the technique “zap-and-freeze” time-resolved electron microscopy. Using this method, they find that synaptic vesicles are recycled via ultrafast endocytosis in human neocortical slices.
Resolving the mysteries of brain clearance and immune surveillance 11/24/2025
This review by Kipnis et al. explores recent advances in brain fluid dynamics, emphasizing CSF flow’s role in waste clearance, the glymphatic and meningeal lymphatic systems, and neuroimmune interactions, with implications for neurodegenerative and neuroimmune disorders.
A transcriptomic atlas of astrocyte heterogeneity across space and time in mouse and marmoset 11/20/2025
In this NeuroResource, Schroeder et al. present a transcriptomic atlas across brain regions and developmental time points in mouse and marmoset. Detailed analysis focused on astrocytes revealed that their embryonically patterned regional heterogeneity changes significantly over the course of postnatal development, with both species conservation and divergence.