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Glucose hypometabolism and hyperphosphorylated Tau synergistically drive neuronal necroptosis 04/22/2026
Chen et al. show that reduced brain glucose metabolism and pathological Tau cooperate to induce neuronal death through necroptosis. By identifying a p-Tau-RIPK1 signaling hub and its regulation by A20, the study reveals a mechanistic link between glucose hypometabolism and neurodegeneration.
Astrocyte cell volume dynamics across cortical states and transitions 04/20/2026
Deng et al. used in vivo two-photon imaging to characterize sleep-wake-dependent changes in astrocyte volume. Using chemogenetic and optogenetic activation of locus coeruleus tyrosine hydroxylase-positive neurons, they show that norepinephrine drives these volume changes, in part via α1-adrenergic receptors.
Dentate gyrus interneurons modulate winner-take-all network dynamics in freely behaving mice 04/20/2026
Hainmueller, Heynold, et al. studied the activity and synaptic interactions of different excitatory and inhibitory neuron types in the dentate gyrus of freely behaving mice. Bidirectional optogenetic manipulations revealed roles for interneurons in selecting cell assemblies through winner-take-all dynamics that go beyond simple circuit suppression.
A bone-derived hormone permits rapid visual escape via GPR37 receptor in a subpopulation of VTA GABAergic neurons 04/18/2026
(Neuron 114, ◼◼◼–◼◼◼; May 6, 2026)