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The Simons Collaboration on Ecological Neuroscience: Studying how the brain interacts with the world 06/09/2026

The Simons Collaboration on Ecological Neuroscience (SCENE) seeks to uncover general principles of brain function through an ecological perspective: studying perception, cognition, and action in the context of the affordances available to different agents. Here, Angelaki et al. introduce SCENE’s goals, hypotheses, and approaches outlining a collaborative vision for the next decade.

Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis 06/09/2026

Microglia-mediated neuroinflammation drives Alzheimer’s disease progression. In this article, Liu et al. show that the histone acetyltransferase KAT7 promotes mitochondrial DNA-dependent inflammation in microglia. Inhibiting KAT7 reduces β-amyloid accumulation, neuroinflammation, and cognitive deficits in Alzheimer’s mouse models, revealing a potential epigenetic target to counteract disease-associated inflammation.

Developmental and age-related synapse elimination is mediated by glial Croquemort 06/08/2026

By exploiting Drosophila to study glial regulation of synapse development and maintenance across the lifespan and performing an in vivo genetic screen, Jay et al. reveal new molecular pathways required for changes in synapse numbers. They characterize the scavenger receptor Crq in detail and show that it is required for developmental and age-related synapse elimination.

Prefrontal gamma oscillations engage dynamic cell-type-specific configurations to support flexible behavior 06/08/2026

Phensy et al. show that prefrontal gamma activity is composed of multiple, cell-type-specific synchrony patterns that differentially manifest during decision-making and outcome periods and track changes in behavioral strategies. These patterns offer a new framework for understanding cognitive flexibility and its disruption in disorders such as schizophrenia.