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POINTseq: Cell-type-specific barcoding reveals single-cell projection architecture of the mouse dopaminergic system 06/04/2026

Kim et al. introduce POINTseq, a high-throughput barcoded connectomics method for mapping brain-wide single-neuron projections of a specific cell population defined by common viral-genetic tools. Applying POINTseq to mouse midbrain dopamine neurons reveals diverse connectomic cell types and stereotyped collateral wiring patterns that may underlie distinct dopamine functions.

A specialized population of hair afferents dedicated to transmitting mechanical itch 06/04/2026

Fatima et al. identify a specialized sensory pathway in mice in which Piezo2-expressing TLR5Calb1 Aβ-LTMRs innervate vellus-like hairs to drive both acute and chronic mechanical itch, revealing a dedicated hair organ for touch-evoked pruritus.

A hypothalamic circuit for anticipating future changes in energy balance 06/03/2026

Walker, Lowenstein, et al. demonstrate that hunger neurons in the mouse hypothalamus are rapidly activated not only by actual energy deficit but also by environmental cues predicting future fasting. This predictive hunger signal is conveyed by upstream Sim2-expressing neurons, revealing that the brain proactively anticipates energy shortfalls before they occur.

A learning-evoked slow-oscillatory architecture paces population activity for offline reactivation across the human medial temporal lobe 06/01/2026

Causse et al. identify a learning-evoked slow-oscillatory architecture in the human medial temporal lobe. Transient hippocampal 2-Hz bursts pace neuronal spiking and synchronize gamma-band activity across the MTL, structuring population coactivity motifs during learning. These coactivity motifs are selectively reactivated during hippocampal ripples during post-learning rest, and reactivation strength predicts subsequent recall, linking encoding, consolidation, […]