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CLN3 mediates chloride efflux from lysosomes 01/19/2026
Wang et al. identify CLN3 as a conserved lysosomal protein that regulates lysosomal chloride homeostasis, pH, and protein degradation. Transcription factor EB (TFEB) activation enhances CLN3 function, revealing the TFEB-CLN3 signaling axis as a promising therapeutic target for lysosomal storage disorders.
Gut-brain cholinergic signaling mediates the antiseizure effects of Bacteroides fragilis 01/16/2026
Jia et al. show that the antiseizure effects of Bacteroides fragilis are mediated by enhanced cholinergic signaling along the gut-vagus-brain axis and reinforced by the gut colonization of Lactobacillus. These findings reveal a microbiota-neural circuit interaction with translational implications for pediatric refractory epilepsy.
Tachykinin signaling defines distinct populations of glia in the enteric nervous system 01/08/2026
To date, glial cells in the enteric nervous system have been categorized by spatial location and morphology. Here, Muppirala et al. define distinct subtypes of enteric glia that align with this spatial classification and identify tachykinin signaling as a key mediator of glial diversification and subtype-specific function in intestinal motility.
A small population of stress-responsive neurons in the hypothalamus-habenula circuit mediates development of depression-like behavior in mice 01/06/2026
(Neuron 112, 3924–3939.e1–e5; December 4, 2024)