ALS Curtis Vance Foundation - Page 2 of 21 - ALS Disease Facts and Information

How to Clear Blocked Nose After Rhinoplasty: A Complete Guide to Managing Nasal Congestion

Rhinoplasty, or nose job surgery, is a popular procedure aimed at enhancing the appearance and functionality of the nose. While …

Rhinoplasty, a nose job, is one of today’s most popular plastic surgery procedures. Many individuals undergo this surgical procedure to …

Rhinoplasty, often called a nose job, is one of the most popular cosmetic procedures worldwide. It can help improve the …

Aberrant hypothalamic neuronal activity blunts glucocorticoid diurnal rhythms in murine breast cancer 12/15/2025
Gomez, Wu, et al. demonstrate that breast cancer promotes blunted glucocorticoid diurnal rhythms via disinhibition of PVNCRH neurons. Restoration of normal glucocorticoid rhythms via endogenous activation of the HPA axis reduces tumor progression and boosts anti-tumor immunity. This neural mechanism offers a novel target for potential anti-cancer therapy.
TDP-43 dysfunction compromises UPF1-dependent mRNA metabolism in ALS 12/12/2025
Alessandrini et al. map UPF1-mediated RNA decay in human motor neurons and show that TDP-43 dysfunction impairs RNA surveillance. UPF1 and TDP-43 proteins interact and co-aggregate in pathological inclusions; they also co-regulate alternative polyadenylation of specific transcripts extending 3′ UTRs, revealing a shared pathway underlying ALS-related RNA dysregulation.
Semaphorin–Neuropilin Interactions Underlying Sympathetic Axon Responses to Class III Semaphorins 12/10/2025
(Neuron 21, 1283–1290; December, 1998)
Sympathetic functional units encoded by genetically defined postganglionic neurons 12/09/2025
Wei et al. found two CG-SMG sympathetic subpopulations: Calb2-positive neurons project to gut muscle, forming endings at myenteric ganglia to regulate motility, and Nxph4-positive neurons innervate organ blood vessels, forming perivascular endings that act as visceral vasoconstrictors controlling blood flow.