ALS Curtis Vance Foundation - Page 5 of 21 - ALS Disease Facts and Information

Is ALS Painful? Unpacking the Complexities of Pain in Lou Gehrig’s Disease

15 Jul 2024admin_alscvf8679Leave a comment

When discussing Amyotrophic Lateral Sclerosis (ALS), a common question arises, iIs ALS painful? This progressive neurodegenerative disease affects nerve cells …

Does ALS Cause Numbness? Exploring Symptoms of Amyotrophic Lateral Sclerosis

10 Jun 2024admin_alscvf8679Leave a comment

Does ALS cause numbness? This question often arises for those trying to understand the complex symptoms of amyotrophic lateral sclerosis. …

Is ALS Contagious? Unveiling the Facts Behind Transmission

9 May 2024admin_alscvf8679Leave a comment

Is ALS contagious? This is a crucial question many ask when they first encounter amyotrophic lateral sclerosis, a neurodegenerative disease …

Other Informations About Neurons

Tau phosphorylation from neuronal adaptation to Alzheimer’s disease 10/09/2026

Trouvé et al. synthesize evidence that Tau phosphorylation is a conserved adaptive response to physiological and cellular stress and propose that tauopathy arises when this normally reversible program becomes persistent, dysregulated, and unable to restore Tau homeostasis.

Orbitofrontal value dynamics and striatal population geometry during interruption of automatic behavior 10/09/2026

Elston and Wallis examined how monkeys use cognitive control to override automatic behavior. Cognitive conflict made OFC value representations volatile and increased oscillatory synchronization with the striatum, which coincided with destabilized striatal coding and halting of the automatic response. This suggests that control operates by “jamming” rather than “suppressing” the striatum.

Stepwise engagement of cingulate ensembles underlies motivational decline in chronic pain 10/09/2026

Xu, Sun, et al. show that neuropathic pain engages anterior cingulate outputs in stages in male mice. Amygdala-projecting neurons contribute to early mechanical hypersensitivity, whereas habenula-projecting neurons contribute to late impairment of effortful persistence. Recurrent cingulate-amygdala signaling offers a candidate route between these stages.

Simultaneous awake replay of multiple spatial representations 10/08/2026

Mou and Ji demonstrate that hippocampal place cell activity representing multiple trajectories are simultaneously replayed during reward consumption in an observational learning task. Simultaneous replay reflects the spatial structure and reward sites in the task, prioritizes correct trajectories, and correlates more with task performance and cortical activity than single replay.