ALS Curtis Vance Foundation - Page 5 of 21 - ALS Disease Facts and Information

Is ALS Painful? Unpacking the Complexities of Pain in Lou Gehrig’s Disease

15 Jul 2024admin_alscvf8679Leave a comment

When discussing Amyotrophic Lateral Sclerosis (ALS), a common question arises, iIs ALS painful? This progressive neurodegenerative disease affects nerve cells …

Does ALS Cause Numbness? Exploring Symptoms of Amyotrophic Lateral Sclerosis

10 Jun 2024admin_alscvf8679Leave a comment

Does ALS cause numbness? This question often arises for those trying to understand the complex symptoms of amyotrophic lateral sclerosis. …

Is ALS Contagious? Unveiling the Facts Behind Transmission

9 May 2024admin_alscvf8679Leave a comment

Is ALS contagious? This is a crucial question many ask when they first encounter amyotrophic lateral sclerosis, a neurodegenerative disease …

Other Informations About Neurons

Unifying the structures of language in a neural population code 08/14/2026

How does language emerge from neural computations in the human brain? In stark contrast to symbolic theories of language, large language models demonstrate how the structures of language can be unified in a high-dimensional neural population code.

Astrocytic NFIX regulates thalamocortical circuits through GABA and purinergic signaling 08/13/2026

Astrocytes play essential roles in brain function by supporting neural circuits and cognition. Murali et al. find that the transcription factor NFIX is required to maintain astrocyte function in the thalamic reticular nucleus through region-specific control of GABA signaling. Altered astrocyte-neuron communication disrupts thalamocortical oscillations, impairing learning and memory.

Status-dependent competition engagement via mesocortical pathway 08/12/2026

Jin et al. establish the win maze to study how mice decide to re-engage in competition after winning outcomes. They show that dominant males display stronger competition engagement, with dmPFC neural dynamics predicting future choices and mesocortical dopamine bidirectionally regulating engagement.

Developmentally defined subcircuits in the hippocampus support spatial learning 08/12/2026

Huszár, Kirsanov et al. show that hippocampal CA3 and CA1 neurons born on the same day form a functional subcircuit that encodes new memories. Spatial learning engaged convergent connectivity from embryonically related pyramidal neurons onto parvalbumin-expressing CA1 interneurons.