signs of lou gehrig disease

Lou Gehrig’s disease, formally known as Amyotrophic Lateral Sclerosis (ALS), is a progressive neurodegenerative disorder that affects nerve cells in the brain and spinal cord. Named after the famous baseball player who brought widespread attention, this disease gradually erodes muscular function, leading to debilitating symptoms and paralysis. Detecting the early signs of Lou Gehrig disease is crucial, not only for understanding the onset of the disease but also for seeking timely intervention. This article delves into ALS’s subtle signals and prominent indicators, providing a comprehensive guide for those wanting to understand and recognize its initial stages.

How does ALS affect your body?

Amyotrophic Lateral Sclerosis (ALS), or Lou Gehrig’s disease, primarily affects the motor neurons in the body. These neurons transmit messages from the brain to the voluntary muscles throughout the body. As the disease progresses, it has various physical impacts on the body. Here’s how ALS affects different systems and parts of the body:

Muscular System: As motor neurons degenerate and die, they cease to send messages to the muscles, causing them to weaken and atrophy. This leads to:

    • Muscle twitching (fasciculations)
    • Muscle cramps
    • Muscle stiffness (spasticity)
    • Muscle weakness that starts in the arms or legs and progressively affects other parts

Respiratory System: As the muscles associated with breathing weaken, respiratory complications arise, a major concern in ALS.

    • Difficulty breathing
    • Shortness of breath
    • Eventually, individuals may need ventilation support to help with breathing.

Speech and Swallowing: The muscles used for speech and swallowing are often affected.

    • Difficulty swallowing (dysphagia), which can lead to choking or aspiration
    • Slurred speech (dysarthria)
    • Change in vocal quality or hoarseness

Mobility: As the disease progresses, mobility becomes a significant issue.

    • Difficulty walking and maintaining balance
    • Increased risk of falls
    • Difficulty with tasks requiring fine motor skills, like buttoning clothes or writing
    • Eventually, the individual may become paralyzed and wheelchair-bound.

Cognitive and Behavioral Changes: Although ALS is primarily a motor neuron disease, some individuals experience cognitive and behavioral changes.

    • Impairments in decision-making, memory, and other cognitive functions
    • A subset of patients might develop frontotemporal dementia (FTD)

Sensory System: Interestingly, ALS does not usually affect a person’s ability to see, smell, taste, hear, or recognize touch.

Pain: As muscles weaken and mobility is affected, individuals might experience pain from muscle stiffness, joint stress, and other mobility-related issues.

Autonomic Nervous System: While ALS primarily affects the voluntary muscles, there can sometimes be effects on the autonomic system, influencing functions like blood pressure and heart rate.

It’s important to note that the progression and presentation of ALS symptoms can vary greatly among individuals. Some might first experience symptoms in the arms or hands, while others notice them in the legs or face. The rate at which ALS progresses also differs, making personalized medical care and monitoring essential for those diagnosed with this condition.

What causes ALS?

signs of lou gehrig disease anatomyThe exact cause of Amyotrophic Lateral Sclerosis (ALS) remains largely unknown, and a combination of genetic, environmental, and molecular factors is likely involved. However, researchers have made several observations and discoveries related to the potential causes and risk factors:

Genetic Factors:

    • Approximately 5-10% of ALS cases are familial, meaning the disease runs in families. In these cases, mutations in specific genes have been identified. For instance, mutations in the C9ORF72, SOD1, TARDBP, and FUS genes are among the most common genetic causes of familial ALS.
    • Even in sporadic cases (those without a family history), genetic factors might still play a role, suggesting a potential interplay of genes and environment.

Environmental Factors:

    • Some studies have suggested that exposure to certain environmental factors, such as heavy metals, pesticides, or solvents, might increase the risk of developing ALS.
    • Military service, especially among Gulf War veterans, has been identified as a potential risk factor, though the reasons for this correlation are still under investigation.
    • Smoking has also been associated with a slightly increased risk of ALS.

Molecular and Cellular Factors:

    • Protein Misfolding: In ALS, proteins can become misshapen and accumulate inside nerve cells, potentially damaging them.
    • Mitochondrial Dysfunction: Mitochondria are the energy-producing structures inside cells. Some evidence suggests that mitochondrial dysfunction might be involved in ALS.
    • Oxidative Stress occurs when there’s an imbalance between the production of free radicals and the body’s ability to counteract their harmful effects. Oxidative stress might contribute to motor neuron damage in ALS.
    • Glutamate Excitotoxicity: Glutamate is a neurotransmitter that, in excessive amounts outside the nerve cells, can cause damage to these cells. In some people with ALS, high levels of glutamate have been found in the spaces between motor neurons, which might contribute to cell damage.
    • Inflammation: Immune system cells might attack the motor neurons, contributing to inflammation and potential damage.

Viral or Bacterial Factors: Some researchers have explored the idea that certain viral or bacterial agents might be associated with ALS, but clear evidence is still lacking.

Physical Trauma: A few studies have suggested that physical injuries, such as head traumas, might be linked to the development of ALS, but this connection is still not firmly established.

Despite the various theories and observations, the exact cause of ALS remains elusive. Current research continues to explore these potential causes, aiming to better understand the disease’s origin, which might eventually lead to more effective treatments or prevention strategies.

Lou Gehrig’s Disease Signs and Symptoms

Amyotrophic Lateral Sclerosis (ALS), commonly called Lou Gehrig’s Disease, affects motor neurons, which are essential for the movement of voluntary muscles. The symptoms of ALS can vary significantly among patients depending on which neurons are affected first. Still, the following is a comprehensive list of signs and symptoms commonly associated with the disease:

  1. Muscle Weakness: Often starts in one part of the body, such as the arm or leg, and spreads to other areas over time. Initial symptoms, like difficulty lifting objects, tripping, or dropping things, might be subtle.
  2. Muscle Atrophy: As the disease progresses, the affected muscles shrink in size.
  3. Muscle Twitching and Cramps: Fasciculations, or muscle twitches, are common in ALS and can be seen or felt under the skin. Muscle cramps can be painful and frequent.
  4. Muscle Stiffness (Spasticity): Muscles may become tight and hard to move.
  5. Speech Difficulties (Dysarthria): Speech may become slurred, nasal-sounding, or soft. Over time, some patients may become difficult to understand or lose the ability to speak entirely.
  6. Difficulty Swallowing (Dysphagia): Choking and coughing while eating or drinking become more common as the disease progresses.
  7. Breathing Problems: Breathing muscles weaken, leading to difficulty taking deep breaths, coughing, and other respiratory functions. As the disease progresses, respiratory failure can occur, and many patients may need assistive devices or ventilators to help with breathing.
  8. Difficulty with Fine Motor Skills: Tasks like buttoning clothes, tying shoelaces, or writing can become challenging.
  9. Changes in Posture and Walking: A person might develop a forward or backward lean or experience difficulty walking, eventually requiring aids like braces or wheelchairs.
  10. Emotional Changes: Emotional lability, characterized by rapid mood changes or excessive emotional reactions, can occur in some ALS patients.
  11. Cognitive and Behavioral Changes: While primarily a motor neuron disease, some individuals may experience changes in memory, decision-making, and other cognitive functions. A subset may develop frontotemporal dementia.

It’s essential to understand that while ALS patients may experience some or many of these symptoms, the exact progression and intensity can vary widely among individuals. Early diagnosis and intervention can help manage the symptoms and improve the quality of life for those affected.

Lou Gehrig’s Disease Risk factors

While the exact cause of Amyotrophic Lateral Sclerosis (ALS), commonly known as Lou Gehrig’s Disease, is still unknown, several risk factors have been identified. It’s worth noting that having one or more of these risk factors does not mean a person will develop ALS, but they may increase the likelihood. Here are the known risk factors:

1. Age: Most people who develop ALS are between the ages of 40 and 60, though it can occur at younger ages.

2. Gender: Before age 65, slightly more men than women develop ALS. This gender difference diminishes with increasing age.

3. Race and Ethnicity: ALS is more common in Caucasians and non-Hispanics.

4. Genetics: Familial ALS, where the disease runs in families, accounts for 5-10% of all cases. In these situations, children have a 50% chance of inheriting the gene mutation from an affected parent. Even sporadic ALS cases (those without a clear family history) might have a genetic component.

5. Environmental Factors:

  • Exposure to Environmental Toxins: Some research suggests that exposure to specific chemicals or heavy metals, like lead, might increase ALS risk.
  • Military Service: Veterans, particularly those who served during the Gulf War, seem to be at a slightly higher risk of developing ALS. The exact reasons for this are still under investigation.
  • Smoking: Smoking, especially in women after menopause, might increase the risk of ALS. The risk seems to decrease after quitting.

6. Physical Trauma: Some studies suggest that head injuries or other traumas might increase the risk of developing ALS, but the evidence is inconclusive.

7. Physical Activity: Studies have explored whether physically active people are at a higher risk of ALS. While some findings suggest a potential link, especially in high-intensity activities, the evidence is not robust, and the topic remains controversial.

8. Other Diseases: Certain conditions, such as the neurodegenerative disease frontotemporal dementia (FTD), have a known association with ALS. Some individuals may present symptoms of both ALS and FTD.

9. Geographical Clusters: Reports of specific regions globally with higher ALS incidences have prompted investigations into possible environmental causes. However, most of these clusters remain unexplained.

It’s essential to understand that these risk factors do not guarantee the development of ALS, nor does their absence ensure immunity from the disease. Many people with ALS have no known risk factors. Continued research aims to better understand these factors and their interplay in the onset of the disease.

How to diagnose ALS

Diagnosing Amyotrophic Lateral Sclerosis (ALS) can be challenging due to its variability in presentation and its overlap with other neurological conditions. Here’s a brief overview:

  1. signs of lou gehrig disease weaknessClinical Examination: A neurologist will perform a thorough physical examination to assess muscle strength, reflexes, and signs of muscle wasting or twitching.
  2. Electromyogram (EMG): An EMG measures the electrical activity of muscles. In ALS, characteristic patterns of electrical activity can be detected when the muscle is at rest and contracted.
  3. Nerve Conduction Study: This test measures the nerves’ ability to send impulses to muscles in different body areas.
  4. Magnetic Resonance Imaging (MRI): While an MRI cannot detect ALS, it can help rule out other conditions that mimic its symptoms, such as tumors, herniated discs, or other neurological disorders.
  5. Blood and Urine Tests: These can help rule out other conditions and check for metabolic issues that might mimic ALS.
  6. Lumbar Puncture (Spinal Tap): By analyzing the cerebrospinal fluid (which surrounds the brain and spinal cord), doctors can rule out other conditions, like infections or inflammation, that might mimic ALS.
  7. Muscle Biopsy: A small piece of muscle might be removed and analyzed if the neurologist suspects another type of muscle disease.
  8. Genetic Testing: Genetic tests can confirm the diagnosis if there’s a family history of ALS.

Given the lack of a definitive test for ALS, the diagnosis often involves ruling out other conditions. The criteria for diagnosing ALS typically involve evidence of upper and lower motor neuron damage that cannot be attributed to other conditions.

Treatment for ALS

According to the ALS Association, unfortunately, ALS has no cure. However, treatments can help manage symptoms, slow disease progression, and improve quality of life.


  • Riluzole (Rilutek): The first drug approved by the FDA specifically for ALS, it can slow the progression of the disease and prolong survival by a few months.
  • Edaravone (Radicava): Approved more recently, it’s believed to reduce oxidative stress in the brain. Some patients have experienced a slowing of disease progression with this drug.

Physical Therapy: Helps patients maintain mobility and strength for as long as possible. Adaptive equipment like braces or wheelchairs can also be introduced as needed.

Occupational Therapy: Helps patients maintain independence in daily activities. Introduces adaptive devices for activities like dressing, eating, and grooming.

Speech Therapy: As ALS progresses, speaking can become difficult. A speech therapist can offer techniques and adaptive devices to aid communication.

Breathing Support: Devices like BiPAP can help improve nighttime breathing as respiratory muscles weaken. Patients may choose to have a tracheostomy for permanent ventilation in advanced stages.

Nutritional Support: Difficulty swallowing can lead to malnutrition. Dietitians can recommend modified diets or feeding tubes if necessary.

Palliative Care: Focuses on improving the quality of life by addressing physical, emotional, and psychological challenges.

Research is ongoing to find more effective treatments and, hopefully, a cure for ALS. Regular consultations with a neurologist and a multidisciplinary care team can ensure that patients receive the best available care for their specific needs.

What exercises can help people with ALS?

Exercise for individuals with Amyotrophic Lateral Sclerosis (ALS) can be beneficial. Still, it’s essential to approach it with care and under the guidance of a healthcare professional, typically a physical therapist. The main exercise goals in ALS are to maintain mobility, manage symptoms, improve function, and enhance overall well-being. Here are some exercises and activities that can be helpful:

  1. signs of lou gehrig disease therapyRange-of-Motion (ROM) Exercises: These involve moving joints through their full range of motion. They can be passive (someone else moves the joint for the patient) or active (the patient moves the joint). They help prevent stiffness and maintain joint health.
  2. Stretching: Gentle stretching can help manage muscle stiffness (spasticity) and maintain muscle and tendon length. Stretching can be static (holding a stretch for a period) or dynamic (moving through a stretch).
  3. Strengthening Exercises: Mild to moderate resistance exercises can help maintain muscle strength. It’s crucial to avoid overexertion or exercises that cause fatigue. The emphasis is on low-intensity and high-repetition exercises.
  4. Aerobic Exercise: Low-impact exercises like walking or seated cycling can be beneficial for cardiovascular health. Aquatic therapy or swimming can also be beneficial, as the buoyancy of water supports the body and reduces the risk of joint stress or muscle strain.
  5. Breathing Exercises: Guided by respiratory therapists, these exercises aim to improve lung function and maximize oxygen intake. Techniques such as diaphragmatic breathing or incentive spirometry can help strengthen respiratory muscles.
  6. Balance and Coordination Exercises: As ALS progresses, balance can be affected. Specific exercises can help improve stability and reduce the risk of falls.
  7. Functional Training: These exercises enhance the ability to perform daily tasks, such as getting out of bed, transferring from a chair, or climbing stairs.
  8. Adaptive Exercise: As the disease progresses, exercises might need to be adapted using equipment like therapy bands, lightweight dumbbells, or exercise balls.


A Few Precautions:

  • Avoid Overexertion: People with ALS should not exercise to the point of fatigue. If muscles are sore over an hour after exercising, it may indicate overexertion.
  • Monitor Breathing: If breathing becomes difficult during exercise, stopping and rest is essential.
  • Stay Hydrated: Drink plenty of fluids before, during, and after exercise.
  • Consult Professionals: Before starting any exercise regimen, consult a neurologist and a physical therapist familiar with ALS. They can help design a program tailored to individual needs.

Remember, while exercise can offer several benefits, listening to the body’s signals and adapting activities as the disease progresses is essential.



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