ALS Curtis Vance Foundation - Page 8 of 21 - ALS Disease Facts and Information

How Long Can You Live with ALS: Unraveling the Layers of Prognosis and Hope

6 Oct 2023admin_alscvf8679Leave a comment

Amyotrophic Lateral Sclerosis (ALS) invariably leads us to confront one of the most poignant and complex questions: How long can …

Spotting the Signals: Unraveling the Early Signs of Lou Gehrig Disease

25 Aug 2023admin_alscvf8679Leave a comment

Lou Gehrig’s disease, formally known as Amyotrophic Lateral Sclerosis (ALS), is a progressive neurodegenerative disorder that affects nerve cells in …

Identifying Early Symptoms: What is Usually the First Sign of ALS?

7 Jun 2023admin_alscvf8679Leave a comment

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a complex and challenging neurological condition that affects thousands …

Polarized Signaling Endosomes Coordinate BDNF-Induced Chemotaxis of Cerebellar Precursors 11/15/2025
(Neuron 55, 53–68; July 5, 2007)
Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution 11/14/2025
Hypertension is a major cause of cognitive decline, but the underlying mechanisms are unclear. Using scRNA-seq in an angiotensin II mouse model, Schaeffer and Pacholko identify early endothelial, interneuron, and oligodendrocyte vulnerability linked to angiotensin II signaling, revealing molecular pathways that drive later neurovascular dysfunction and cognitive impairment in hypertension.
Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism 11/13/2025
Claims that the gut microbiome causally contributes to autism regularly appear in the scientific literature and popular press. Mitchell et al. critically examine influential studies underpinning these claims and find them conceptually and methodologically flawed.
Globally patterned locus coeruleus-norepinephrine neuron-pericyte coupling orchestrates brain-wide vascular dynamics 11/12/2025
Through whole-brain neurovascular imaging in larval zebrafish, Sun and Peng et al. show that the locus coeruleus-norepinephrine (LC-NE) system orchestrates globally patterned pericyte activities through complementary direct NE and indirect glia-relayed actions. Such LC-NE neuron-pericyte coupling exerts global vasoconstrictive drives that coordinate blood flow and support sustained behavioral performance.