ALS Curtis Vance Foundation - Page 8 of 21 - ALS Disease Facts and Information

How Long Can You Live with ALS: Unraveling the Layers of Prognosis and Hope

6 Oct 2023admin_alscvf8679Leave a comment

Amyotrophic Lateral Sclerosis (ALS) invariably leads us to confront one of the most poignant and complex questions: How long can …

Spotting the Signals: Unraveling the Early Signs of Lou Gehrig Disease

25 Aug 2023admin_alscvf8679Leave a comment

Lou Gehrig’s disease, formally known as Amyotrophic Lateral Sclerosis (ALS), is a progressive neurodegenerative disorder that affects nerve cells in …

Identifying Early Symptoms: What is Usually the First Sign of ALS?

7 Jun 2023admin_alscvf8679Leave a comment

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a complex and challenging neurological condition that affects thousands …

Tau phosphorylation from neuronal adaptation to Alzheimer’s disease 10/09/2026
Trouvé et al. synthesize evidence that Tau phosphorylation is a conserved adaptive response to physiological and cellular stress and propose that tauopathy arises when this normally reversible program becomes persistent, dysregulated, and unable to restore Tau homeostasis.
Orbitofrontal value dynamics and striatal population geometry during interruption of automatic behavior 10/09/2026
Elston and Wallis examined how monkeys use cognitive control to override automatic behavior. Cognitive conflict made OFC value representations volatile and increased oscillatory synchronization with the striatum, which coincided with destabilized striatal coding and halting of the automatic response. This suggests that control operates by “jamming” rather than “suppressing” the striatum.
Stepwise engagement of cingulate ensembles underlies motivational decline in chronic pain 10/09/2026
Xu, Sun, et al. show that neuropathic pain engages anterior cingulate outputs in stages in male mice. Amygdala-projecting neurons contribute to early mechanical hypersensitivity, whereas habenula-projecting neurons contribute to late impairment of effortful persistence. Recurrent cingulate-amygdala signaling offers a candidate route between these stages.
Simultaneous awake replay of multiple spatial representations 10/08/2026
Mou and Ji demonstrate that hippocampal place cell activity representing multiple trajectories are simultaneously replayed during reward consumption in an observational learning task. Simultaneous replay reflects the spatial structure and reward sites in the task, prioritizes correct trajectories, and correlates more with task performance and cortical activity than single replay.