ALS Curtis Vance Foundation - Page 8 of 21 - ALS Disease Facts and Information

How Long Can You Live with ALS: Unraveling the Layers of Prognosis and Hope

6 Oct 2023admin_alscvf8679Leave a comment

Amyotrophic Lateral Sclerosis (ALS) invariably leads us to confront one of the most poignant and complex questions: How long can …

Spotting the Signals: Unraveling the Early Signs of Lou Gehrig Disease

25 Aug 2023admin_alscvf8679Leave a comment

Lou Gehrig’s disease, formally known as Amyotrophic Lateral Sclerosis (ALS), is a progressive neurodegenerative disorder that affects nerve cells in …

Identifying Early Symptoms: What is Usually the First Sign of ALS?

7 Jun 2023admin_alscvf8679Leave a comment

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a complex and challenging neurological condition that affects thousands …

Unifying the structures of language in a neural population code 08/14/2026
How does language emerge from neural computations in the human brain? In stark contrast to symbolic theories of language, large language models demonstrate how the structures of language can be unified in a high-dimensional neural population code.
Astrocytic NFIX regulates thalamocortical circuits through GABA and purinergic signaling 08/13/2026
Astrocytes play essential roles in brain function by supporting neural circuits and cognition. Murali et al. find that the transcription factor NFIX is required to maintain astrocyte function in the thalamic reticular nucleus through region-specific control of GABA signaling. Altered astrocyte-neuron communication disrupts thalamocortical oscillations, impairing learning and memory.
Status-dependent competition engagement via mesocortical pathway 08/12/2026
Jin et al. establish the win maze to study how mice decide to re-engage in competition after winning outcomes. They show that dominant males display stronger competition engagement, with dmPFC neural dynamics predicting future choices and mesocortical dopamine bidirectionally regulating engagement.
Developmentally defined subcircuits in the hippocampus support spatial learning 08/12/2026
Huszár, Kirsanov et al. show that hippocampal CA3 and CA1 neurons born on the same day form a functional subcircuit that encodes new memories. Spatial learning engaged convergent connectivity from embryonically related pyramidal neurons onto parvalbumin-expressing CA1 interneurons.